Table 6. NTM sensitivity and specificity compared with the reference results of culture, PCR, and sequencing (number of MTBC samples=396).
EZplex MTBC/ NTM Real-time PCR | Reference results (culture, PCR, sequencing) | Sensitivity (95% CI, %) | Specificity (95% CI, %) | PPVa) (95% CI) | NPVa) (95% CI) | ||
---|---|---|---|---|---|---|---|
Positive | Negative | Total | |||||
Positive | 139 | 0 | 139 | 100 (96.6–100) | 100 (98.2–100) | 100 (97.4–100) | 100 (98.6–100) |
Negative | 0 | 257 | 257 | ||||
Total | 139 | 257 | 473 |
NTM, nontuberculous mycobacteria; PCR, polymerase chain reaction; MTBC, Mycobacterium tuberculosis complex; CI, confidence interval; PPV, positive predictive value; NPV, negative predictive value.
a)The PPV and NPV are the proportion of positive and negative results in diagnostic tests, considered as the true positive and true negative results.