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. Author manuscript; available in PMC: 2019 Aug 1.
Published in final edited form as: Curr Opin Biotechnol. 2018 Mar 26;52:74–79. doi: 10.1016/j.copbio.2018.02.016

Figure 1.

Figure 1

Overview of VLR structure. (A) Ribbon structure of a monomeric VLR in complex with an H-trisaccharide (gray) (PDB code 326J [16]). Below the ribbon structure is a modular rendition of a full-length VLR consisting an N-terminal cap (LRRNT), the first leucine-rich repeat (LRR) module (LRR1), three variable LRR (LRRVs), an end variable LRR (LRRVe), a connecting peptide (CP), a C-terminal cap (LRRCT), an invariant stalk, a glycosylphosphatidylinositol (GPI) anchor, and a hydrophobic region. (B) The VLR structure is rotated 90° with highly variable residues of the 6-residue motif (X1LX3LX5X6) in purple and the variable sized insert of the LRRCT in dark blue. X represents highly variable amino acids and L, leucine.