Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 8;8:11876. doi: 10.1038/s41598-018-30195-1

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Thermostability of CYP3A4 polymorphic variants at 34 °C. (A) Graphs showing the decrease in P450 content at 34 °C over 30 minutes. A one phase exponential decay model was fitted to the data using non-linear regression as described in Methods. (B) Comparison of % P450 remaining when the graph reached a low plateau for each variant. (C) Comparison of the half-life of each variant at 34 °C. Error bars represent the standard deviation of three replicates. Student t-test was used to determine values significantly different from WT: *P < 0.05, **P < 0.01, ***P < 0.005.