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. 2018 Aug 8;8:11876. doi: 10.1038/s41598-018-30195-1

Figure 5.

Figure 5

Thermostability of CYP2C9 polymorphic variants at 48 °C. (A) Graphs showing the decrease in P450 content at 48 °C over 30 minutes. A one phase exponential decay model was fitted to the data using non-linear regression as described in Methods. (B) Comparison of % P450 remaining when the graph reaches a plateau for each variant. (C) Comparison of the half-life of each variant at 48 °C. Error bars represent the standard deviation of three replicates. Student t-test was used to determine values significantly different from WT: *P < 0.05, **P < 0.01, ***P < 0.005.