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. 2018 Aug 8;8:11876. doi: 10.1038/s41598-018-30195-1

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Thermostability of CYP2C9 polymorphic variants at 48 °C. (A) Graphs showing the decrease in P450 content at 48 °C over 30 minutes. A one phase exponential decay model was fitted to the data using non-linear regression as described in Methods. (B) Comparison of % P450 remaining when the graph reaches a plateau for each variant. (C) Comparison of the half-life of each variant at 48 °C. Error bars represent the standard deviation of three replicates. Student t-test was used to determine values significantly different from WT: *P < 0.05, **P < 0.01, ***P < 0.005.