Fig. 3. Connectome ring representation of ROI-to-ROI connectivity between anterior cingulate cortex (ACC), left amygdala and insula in the fearful condition.

Only significant connectivity discordances are represented: greater ROI-to-ROI connectivity in the fearful condition for twins with greater methylation level: between ACC and left amygdala (T = 2.79, p = 0.004), as well as between ACC and left insula (T = 1.85, p = 0.035). The color bar represents T values. The bars plot in the top right-hand corner represents differences in effect sizes (difference in Fisher-transformed correlation coefficients) between twins with greater methylation level and their co-twins with lower methylation level, for each connection