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. 2018 Aug 8;8:11894. doi: 10.1038/s41598-018-30426-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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PPARγ inhibits hepatocellular proliferation during mouse liver regeneration (A) Hepatic PPARγ expression during mouse liver regeneration. Representative Immunohistochemistry (IHC) analysis for PPARγ in untreated mice, (B) rosiglitazone-treated mice, and (C) GW9662-treated mice at different time points after PH. Scale bar: 200 μm. Arrow: Centrilobular zone, Arrowhead: Periportal zone. (D) Hepatic expression of PPARγ protein in control mice, rosiglitazone-treated mice and GW9662-treated mice at different time points after partial hepatectomy. (E) Quantification of Western blots after analysis of three biological triplicates. (F) Analysis of cellular localization of PPAR gamma at different time points after PH in wild type mice. *p < 0.05.