Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 8;8:11893. doi: 10.1038/s41598-018-30338-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Latexin expression in melanoma is inversely correlated with patient survival whereas IGFBP7 expression in melanoma is positively correlated with patient survival. (A) Kaplan-Meier overall-survival analysis (OS): Latexin (LXN) expression in melanoma samples was visualized by LXN specific immunohistochemistry in melanoma samples from 105 patients. Patients were grouped as LXN 0–1 (no or low LXN staining) or LXN 2–3 (medium or high LXN staining). LXN low patients show a significantly longer overall survival than LXN high patients (p < 0.001). (B) A melanoma with high LXN expression: Immunohistochemical staining of paraffin embedded patient tissue for LXN. (C) A melanoma with low LXN expression: Immunohistochemical staining of paraffin embedded patient tissue for LXN. (D) Kaplan-Meier overall-survival analysis (OS): IGFBP7 expression in melanoma samples was visualized by IGFBP7 specific immunohistochemistry in melanoma samples from 101 patients. Patients were grouped as IGFBP7 low (no or low IGFBP7 staining) or IGFBP7 high (high or very high IGFBP7 staining). IGFBP7 high patients show a significantly higher overall survival than IGFBP7 low patients (p = 0.003). (E) A melanoma with high IGFBP7 expression: Immunohistochemical staining of paraffin embedded patient tissue for IGFBP7. (F) A melanoma with low IGFBP7 expression: Immunohistochemical staining of paraffin embedded patient tissue for IGFBP7.