Figure 3.

Rosuvastatin decreased blood-brain barrier (BBB) leakage. (A) In the peri-infarct area indicated by the white box, images were captured and tissue samples were collected, as shown in the HT group as an example. (B) Representative photomicrographs of sections stained with 4′,6-diamidino-2-phenylindole (DAPI) and biotin from the peri-infarct areas of the brain at 24 h after reperfusion. Scale bar = 50 μm. (C) Relative biotin leakage ratios were analyzed by the ratio of biotin- to DAPI-positive cells in each group (n = 3 in each group). Values were expressed as the mean ± SEM, the determination of which was followed by the LSD test (homogeneity of variance was determined). *P < 0.05 vs. the SHAM group, ^#P < 0.05 vs. the HT group, ^&P < 0.05 vs. the HT+LRO group.