Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Aug 2;9:847. doi: 10.3389/fphar.2018.00847

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2018 Zhang, Liu, Yu, Liu, Wang, Chen, Bian, Ji, Zhou, Chen, Ji, Xiang, Guo, Fang, Sun, Cao, Zhu and Yu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Cell cycle and ERK1/2 signaling pathway affected by interfering or enforcing UBE2C expression. (A) Cell cycle detected after release of thymidine blockage at 0 and 16 h. The percentage of cells in G₂/M phase was significantly higher (25.79%) in siUBE2C group than that in siNC group (0.03%). (B) Knockdown of UBE2C decreased ERK1/2 phosphorylation and overexpression of UBE2C promoted ERK1/2phosphorylation. (C) U0126 reversed phosphorylated ERK1/2 level caused by UBE2C overexpression. (D) Migration (upper) and invasion (lower) inhibited by U0126 treatment in SGC-7901 cells. Experiments were performed in triplicates. **p < 0.01.