Figure 4.

Perturbation of attractors with differentiation signals. (A) Inputs representing extracellular signals that regulate NK differentiation (Flt3L, Il-7, Delta, and IL-15) were perturbed in all the steady states. The diagram shows the only five perturbations that result in a change of state, which correspond to biological transitions during the differentiation process. (B) Destiny map after perturbing each node. The black arrow corresponds to physiological transitions between cells, the gray dotted line to a transition to a previous state, and the blue dotted line to transition between distinct cell types.