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. 2018 Aug 2;9:1756. doi: 10.3389/fimmu.2018.01756

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Copyright © 2018 Julander, Testori, Cheminay and Volkmann.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Log₁₀ plaque reduction neutralization titers to YF virus (YFV) were significantly elevated in hamsters vaccinated with MVA-BN YF ± adjuvant or with YF-VAX^® compared with animals vaccinated with vehicle [Tris-buffered saline (TBS)] ± adjuvant or untreated normal controls (n = 10/group). (B) Vaccination was protective in animals challenged with YFV and (C) serum levels of alanine aminotransferase on day 6 and (D) time-course weight change was improved in hamsters immunized with MVA-BN YF or YFVAX^® (***p < 0.001, when compared with vehicle).