TABLE 1:

Pregnancy characteristics of women enrolled in the DNBC who completed a revised recruitment form by prenatal intake of folate and multivitamins (−4 to 8 weeks), at baseline and 7-year Follow-up ^* ^¥

	Non Supplement Users		All Women				7yr Follow-up
	Non Supplement Users		Folic Acid		Multivitamin		Folic Acid		Multivitamin
	11916	%	7126	%	17 505	%	4390	%	10101	%
Maternal age (years)
≤ 24	1606	13.5	407	5.7	1550	8.9	231	5.3	791	7.8
25–29	4304	36.2	2690	37.8	7112	40.7	1665	37.9	4124	40.8
30–34	4046	34.0	2807	39.5	6225	35.6	1732	39.5	3635	36.0
≥ 35	1940	16.3	1205	17.0	2605	14.9	762	17.4	1551	15.4
Paternal age (years)
≤ 24	701	6.1	161	2.3	650	3.8	86	2.0	356	3.6
25–29	3085	26.8	1801	26.0	4739	27.7	1124	26.2	2723	27.6
30–34	4215	36.7	2799	40.4	6661	39.0	1754	40.9	3844	38.9
35–39	2458	21.4	1596	23.0	3653	21.4	961	22.4	2116	21.4
40–44	790	6.9	452	6.5	1043	6.1	284	6.6	635	6.4
≥ 45	253	2.2	125	1.8	337	2.0	77	1.8	204	2.1
Parity
0	6571	56.4	3239	46.2	8299	48.3	1954	45.1	4717	47.5
>1	5090	43.7	3766	53.8	8892	51.7	2380	54.9	5210	52.5
Maternal pre-pregnancy RMI
<18.5	459	4.3	288	4.3	716	4.4	168	4.0	420	4.4
18.5–25	6827	63.5	4576	68.8	10932	67.4	2947	70.7	6635	69.8
≥26	3465	32.2	1788	26.9	4577	28.2	1051	25.2	2452	25.8
Maternal smoking
Never	7903	68.0	5684	80.7	13133	76.0	3595	82.0	7867	78.1
≤ 9 cigarettes/day	1620	13.9	738	10.5	2176	12.6	434	9.9	1236	12.3
> 9 cigarettes/day	2102	18.1	622	8.8	1962	11.4	353	8.1	972	9.7
Maternal alcohol consumption
Never	3951	34.0	2248	31.9	5870	34.0	1343	30.7	3293	32.7
0–4 glasses per week	3958	34.1	2907	41.3	6596	38.2	1842	42.0	3905	38.8
more than 4 glasses per week	3716	32.0	1889	26.8	4805	27.8	1197	27.3	2876	28.6
History of Mental Health Illness^§
Yes	287	2.4	137	1.9	389	2.2	66	1.5	171	1.7
No	11629	97.6	6989	98.1	17116	97.8	4324	98.5	9930	98.3
Offspring sex^¶§
Female	5843	49.1	3468	48.8	8498	48.6	2137	48.7	4901	48.5
Male	6053	50.9	3641	51.2	8994	51.4	2253	51.3	5200	51.5
Birth weight (grams)
<2500	483	4.1	220	3.1	593	3.4	128	2.9	281	2.8
2500–4500	10917	91.8	6576	92.5	16132	92.2	4070	92.7	9385	92.9
>4500	496	4.2	313	4.4	767	4.4	192	4.4	435	4.3
Gestational age (weeks)^¶
<37	587	4.9	353	5.0	846	4.8	221	5.0	463	4.6
37–42	10186	85.8	6153	86.7	15200	87.0	3800	86.7	8815	87.3
> 42	1102	9.3	593	8.4	1428	8.2	364	8.3	815	8.1
Apgar Score^¶§
Less than 10	900	7.6	566	8.0	1364	7.9	338	7.7	747	7.5
Score of 10	10924	92.3	6500	92.0	16032	92.1	4028	92.3	9310	92.5
Season when Pregnancy Started
Fall	2422	20.4	1670	23.5	4290	24.6	1041	23.7	2561	25.4
Winter	2969	25.0	1833	25.8	4337	24.8	1137	25.9	2542	25.2
Spring	3674	30.9	1878	26.4	4531	25.9	1166	26.6	2571	25.5
Summer	2810	23.7	1718	24.2	4316	24.7	1041	23.7	2419	24.0
Household Socio-economic status
Higher-grade professionals	2084	19.0	1977	29.3	3963	24.1	1257	29.9	2420	25.1
Middle-grade professionals	2953	26.9	2359	35.0	5485	33.3	1554	37.0	3367	34.9
Skilled work	3567	32.5	1543	22.9	4407	26.8	917	21.8	2506	26.0
Unskilled work	1958	17.8	652	9.7	2091	12.7	355	8.4	1079	11.2
Student	261	2.4	171	2.5	362	2.2	100	2.4	200	2.1
Unemployed > 1year	134	1.2	26	0.4	122	0.7	15	0.4	48	0.5
Unclassified	33	0.3	13	0.2	33	0.2	8	0.2	20	0.2

Missing values: 46 maternal age, 984 paternal age, 592 smoking, 592 alcohol consumption, 658 parity, 2820 pre-pregnancy BMI, 46 sex, 46 birth weight, 92 gestational age, 92 season when pregnancy started, 227 APGAR, 2273 household socio-economic status

^¥

P-values comparing folate and multivitamin supplement users to non-users are <0.05 unless otherwise specified

^¶

Chi-squared p-value comparing folate supplement users (−4 to 8 weeks) to non-users >0.05

^§

Chi-squared p-value comparing multivitamin users (−4 to 8 weeks) to non-users >0.05