Figure 1.

Expression of LINC00460 in CRC Tissues and Its Clinical Parameters

(A) Hierarchical clustering analysis of lncRNAs that were differentially expressed (fold change > 2; p < 0.05) in CRC and normal tissues and overlap of upregulated lncRNAs in TCGA data and GEO datasets. (B) The full sequence of LINC00460 is published in the NCBI database (NR_034119.1). (C) Chromosomal location of LINC00460 and PhyloCSF predicted that LINC00460 has no protein coding potential. The tracks showed the PhyloCSF scores for each codon in each of six frames. Regions with a score greater than 0 were predicted to be coding regions, and regions with a score less than 0 were predicted to be noncoding regions. (D) LINC00460 was detected in 60 pairs of CRC tissues by real-time qPCR. The levels of LINC00460 in CRC tissues are significantly higher than those in non-tumorous tissues. (E) Patients with high levels of LINC00460 expression showed reduced survival times compared with patients with low levels of LINC00460 expression (p = 0.0172; log-rank test). *p < 0.05; **p < 0.01.