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. 2018 Mar 8;67(3):349–359. doi: 10.1538/expanim.17-0137

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©2018 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 4. — SCB-MSCs display enhanced proliferative capacity. A: CCK-8-based cell proliferation assay indicated that the SCB-MSC group harbors stronger proliferative potential than the BMS-MSC group (*P<0.05). B: CFSE data on days 2 and 4 showed that a greater proportion of SCB-MSCs underwent cell division, indicating enhanced proliferation potential. C: The results of cell cycle analysis showed a higher percentage of SCB-MSCs (50 ± 1.41%) were in the S phase compared to BMS-MSCs (36.5 ± 3.55%). D: The data showed enhanced Erk1/2 phosphorylation in passages 3 and 6 SCB-MSCs. SCB-MSCs, subchondral bone-derived MSCs; BMS-MSC, bone marrow suspension-derived MSCs.