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. 2018 Apr 25;67(3):373–382. doi: 10.1538/expanim.17-0131

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©2018 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 4. — Effect of STF-083010 administration on the inflammatory response of ARF kidneys (n=6). Based on the statistical analyses, induction of the ARF model increased the levels of TNF-α (A), IL-1β (B), and MPO (C), while the administration of STF-083010 suppressed the levels of the three indicators. *P<0.001 vs. Sham. ^#P<0.001 vs. Model. Sham group, rats underwent exposure of kidneys without clamping. Model group, rats underwent induction of ARF by clamping. Mock group, ARF rats receiving injection of DMSO. STF-083010 group, ARF rats receiving treatment with STF-0830101.