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. 2018 Apr 25;67(3):373–382. doi: 10.1538/expanim.17-0131

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©2018 Japanese Association for Laboratory Animal Science

This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives (by-nc-nd) License. (CC-BY-NC-ND 4.0: https://creativecommons.org/licenses/by-nc-nd/4.0/)

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Fig. 5. — Effect of STF-083010 administration on ER stress of ARF kidneys (n=6). As illustrated by western blotting, establishment of the ARF model increased the expressions of GRP78, p-IRE, XBP1s, CHOP (A–C) and the activity of caspase 3 (A). The expression patterns of the above indicators were reversed by the administration of STF-083010. *P<0.001 vs. Sham. ^#P<0.001 vs. Model. Sham group, rats underwent exposure of kidneys without clamping. Model group, rats underwent induction of ARF by clamping. Mock group, ARF rats receiving injection of DMSO. STF-083010 group, ARF rats receiving treatment with STF-0830101.