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. 2001 Oct 23;98(23):13108–13113. doi: 10.1073/pnas.231148598

Figure 3.

Figure 3

The calcineurin inhibitor cain/cabin-1 prevents the up-regulation of MyHC-slow and the activation of MyHC-slow promoter in regenerating soleus muscle. Serial cross sections of regenerating soleus muscle transfected with myc-tagged cain and stained with anti-myc (a) or anti-MyHC-slow (b) antibodies. Note that the two fibers expressing myc-tagged cain do not express MyHC-slow, unlike most surrounding untransfected fibers. (c) Cotransfection of MyHC-slow promoter and cain shows that MyHC-slow promoter activity is down-regulated by cain.