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. 2018 Jun 4;15(8):3404–3416. doi: 10.1021/acs.molpharmaceut.8b00407

Figure 1.

Figure 1

Complex 1 induces filamentous growth and decreased protein production in E. coli. Bright field and fluorescent imaging of E. coli cells. (A) N. C. control, (B) cisplatin, (C) compound 1 with light, (D) compound 1 in the dark. Size distribution histograms of E. coli cells associated with the conditions for (A–D): (E) N. C. control, (F) cisplatin, (G) compound 1 with light, (H) compound 1 in the dark. Histograms of average fluorescence intensity correlated to cell size with the different treatments: (I) N. C. control, (J) cisplatin, (K) compound 1 with light, (L) compound 1 in the dark. Cells were treated with 100 μM of each compound for 6 h before imaging.