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. 2018 Jun 4;15(8):3404–3416. doi: 10.1021/acs.molpharmaceut.8b00407

Table 2. Cellular Metal Uptake and Metal Content with Different Nucleic Acids Measured by AAS.

  E. coli
HL60
  cellular uptakea DNA nt/mcb RNA nt/mcc cellular uptakea DNA nt/mcb RNA nt/mcc
1 light 10% 2000 ± 200 3800 ± 600 0.64% 4800 ± 400 5000 ± 700
1 dark 2% -d -d 0.11% -d -d
cisplatin 6% 3000 ± 200 4700 ± 900 0.72% 7000 ± 200 7800 ± 700
a

Cellular uptake was calculated as metal content measured in cells divided by total metal content in both cell samples and cell culture media samples.

b

DNA nt/mc was calculated as DNA nucleotide bases (μmol) divided by metal content measured in DNA sample (μmol).

c

RNA nt/mc was calculated as RNA nucleotide bases (μmol) divided by metal content measured in DNA sample (μmol).

d

Ruthenium levels in DNA and RNA samples were under the detection limit (<2 ppb).