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The MR model using a variant that disrupts normal function of the exposure (IL6R classical signaling), indirectly measured through increased levels of s-IL6R and IL6. The following are the 3 principles of MR analysis: a genetic instrument is robustly associated with the exposure (assumption 1, continuous arrow) but not with confounders (assumption 2, dotted arrow). The genetic variant is associated with the disease only through its effects on the exposure (assumption 3, dotted arrow).
