Table 1. Comparison of colistin MICs determined by Sensititre and the CLSI broth macrodilution reference method.
Sensititre MIC (μg/mL) | No. isolates with initial/final colistin reference MIC (μg/mL)a |
||||||
No. isolates | ≥0.5 | 1 | 2 | 4 | 8 | >8 | |
<0.25 | 74 | 67/69 | 2 | 2b/3b | 1b,c/0 | 2c,d/0 | - |
0.5 | 4 | 4 | - | - | - | - | - |
1 | - | - | - | - | - | - | - |
2 | 4 | - | - | - | 2c/3c | 1b,c/1b,c | 1b,c/0 |
4 | 2 | - | - | - | - | 2b | - |
>4 | 22 | - | - | - | - | 1 | 21 |
Total | 106 | 71/73 | 2 | 2/3 | 3 | 6/4 | 22/21 |
Determined by CLSI broth macrodilution method.
Minor errors if a susceptible breakpoint of ≤1 μg/mL, an intermediate breakpoint of 2–4 μg/mL, and a resistant breakpoint of >8 μg/mL were applied.
Very major errors if EUCAST breakpoints (≤2 μg/mL, susceptible; ≥4 μg/mL, resistant) were applied.
Very major errors if a susceptible breakpoint of ≤1 μg/mL, an intermediate breakpoint of 2–4 μg/mL, and a resistant breakpoint of ≥8 μg/mL were applied.