Table 4.

Multivariate associations with fatigue, including both RA-specific and non-RA-specific risk factors

	Multivariate
	Model 1	Model 2	Model 3
	β (p)	β (p)	β (p)
RA-specific risk factors
RA Disease Activity Index (RADAI)	0.21 (.06)	0.23 (.01)	0.25 (.009)
Functional limitations, HAQ	0.11 (0.65)	---	---
Other risk factors
PSQI total score	0.12 (.01)	0.15 (.0003)	0.13 (.004)
PHQ score	0.10 (.009)	0.08 (.02)	0.10 (.01)
Physical inactivity*	0.28 (.32)	0.27 (.28)	---
Obesity †	0.65 (.04)	0.83 (.001)	0.85 (.001)
Lean mass / fat mass	−0.11 (.43)	---	---
Smoking, now	0.81 (.12)	0.71 (.15)	0.80 (.12)
Model F value (df)	16.07 (8)	21.30 (6)	25.19 (5)
Model R2	0.52	0.51	0.51
Model adjusted R2	0.49	0.49	0.49
F-test for difference in model compared to Model 1, F (p)		0.70 (.50)	1.42 (0.24)

^*Defined as <150 minutes of moderate or vigorous activity in responses to International Physical Activity Questionnaire (IPAQ)

^†Women: BMI ≥ 26.1; men BMI ≥ 24.7 [31]

Model 1: In the initial multivariate model, all variables with p<0.40 in separate RA-specific and non-RA-specific multivariate models were included.

Model 2: Variables with p>0.40 were deleted (HAQ, lean mass)

Model 3: Inactivity deleted