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. 2018 Aug 8;38(32):7179–7191. doi: 10.1523/JNEUROSCI.0721-18.2018

Figure 6.

Figure 6.

Reducing AMPA receptor desensitization with 2 mm aniracetam (+A) altered mEPSCs in neurons expressing WT Syb2 and the WW double-tryptophan mutant. Effects of aniracetam on (A) amplitude, (B) area, (C) max-rise-rate, and (D) decay time. Cell numbers: Syb2 = 28, Syb2+A = 22, WW = 27, and WW+A = 24. For amplitudes the two-tailed t test gave p = 8.0 × 10−4 (WT) and 4.8 × 10−5 (WW) for the significance of the aniracetam effect. For areas p = 3.8 × 10−5 (WT) and 2.6 × 10−8 (WW). Aniracetam had no significant effect on max-rise-rate for WT but the small reduction was significant with the WW mutation (p = 0.042). For decay time the effect was not significant for WT but was for WW (p = 1.5 × 10−4). E, Averaged mEPSC traces for WT Syb2 (top) and WW mutant (bottom) in the absence (black) or presence (gray) of aniracetam. Averages on the right were normalized to their peaks to highlight the differences in decays. *p < 0.05, **p < 0.01, ***p < 0.001.