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. 2018 Aug 8;38(32):7120–7131. doi: 10.1523/JNEUROSCI.0493-18.2018

Figure 4.

Figure 4.

Ablation of RGS9–2 enhances AMPA/NMDA ratio in D2-MSNs. A, Schematic shows whole-cell patch-clamp recording on dorsal striatal MSNs. A concentric bipolar electrode was used to evoke EPSCs located ∼200 μm away dorsal from the soma. B, Representative traces and summarized bar graph show that genetic deletion of RGS9–2 significantly enhanced the AMPA/NMDA ratio in D2-MSNs (t(33) = 2.2, p = 0.033). C, Representative traces and summarized bar graph show that the AMPAR/NMDA ratio was comparable between Rgs9+/+ and Rgs9−/− neurons in D1-MSNs (t(32) = 1.0, p = 0.33). Bar represents number of animals and cells used in each group. *p < 0.05, significantly different between groups.