Figure 2.

Venn diagram of genes involved in depression with significant differential methylation. This figure shows a set of 13 genes identified from our dataset with significant differential methylation resulting from citalopram treatment overlapping with a curated list of genes implicated in psychological depression according to the current IPA database, shown in Venn diagram form. Genes are classified according to their subcellular location, p value, and expression value where positive expression values indicate upregulation and negative expression values represent downregulation. A few important genes included in this list are OXT, GRIN1, CHAT, and CACNA1D which are potential regulators of neurophysiological processes and have a high degree of implication in psychological disorders.