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. 2018 Jul 25;2018:8929057. doi: 10.1155/2018/8929057

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Copyright © 2018 Riya R. Kanherkar et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Cyclins and cell cycle regulation is the top pathway downregulated by citalopram treatment. This figure represents the cyclins and cell cycle regulation pathway as the top signaling pathway downregulated with a significant p value (p value = 1.98E − 02) due to citalopram treatment. IPA identifies this pathway as it involves differentially methylated genes from our dataset like cyclin B, HDAC, and P2A that are upregulated (red) and cyclin D1 and Dp1 that are downregulated (green). The color intensity is proportional to the extremity of upregulation or downregulation.