Table 2.

Quantification of SPLs (VIP > 1) in A549 and A549T

SPLs	Content (pmol/5*105 cells)		ChangeA549T vs A549	p value	VIP
	A549 (n = 20)	A549T (n = 20)
SM (d18:2/20:0)	1.96 ± 0.16	0.53 ± 0.07	↓	< 0.001	1.07408
SM (d18:1/26:1)	19.8 ± 1.22	0.34 ± 0.04	↓	< 0.001	1.08696
SM (d18:1/26:0)	5.67 ± 0.31	0.20 ± 0.02	↓	< 0.001	1.08775
SM (d18:1/25:1)	9.28 ± 0.43	0.45 ± 0.05	↓	< 0.001	1.08860
SM (d18:1/25:0)	4.09 ± 0.23	0.42 ± 0.04	↓	< 0.001	1.08699
SM (d18:1/24:3)	3.34 ± 0.26	0.47 ± 0.07	↓	< 0.001	1.08120
SM (d18:1/24:2)	32.5 ± 1.55	8.99 ± 0.87	↓	< 0.001	1.08501
SM (d18:1/24:1)	542 ± 23.8	37.9 ± 2.59	↓	< 0.001	1.08879
SM (d18:1/24:0)	298 ± 13.0	41.5 ± 3.16	↓	< 0.001	1.08829
SM (d18:1/23:2)	1.12 ± 0.11	0.25 ± 0.04	↓	< 0.001	1.06488
SM (d18:1/23:1)	21.6 ± 1.08	2.58 ± 0.30	↓	< 0.001	1.08745
SM (d18:1/23:0)	26.4 ± 1.26	6.57 ± 0.51	↓	< 0.001	1.08618
SM (d18:1/22:2)	1.25 ± 0.12	0.15 ± 0.02	↓	< 0.001	1.07067
SM (d18:1/22:1)	16.4 ± 0.81	2.07 ± 0.18	↓	< 0.001	1.08760
SM (d18:1/22:0)	142 ± 6.17	26.9 ± 1.78	↓	< 0.001	1.08783
SM (d18:1/21:1)	0.82 ± 0.07	0.15 ± 0.02	↓	< 0.001	1.07308
SM (d18:1/21:0)	4.66 ± 0.25	1.39 ± 0.12	↓	< 0.001	1.08216
SM (d18:1/20:1)	0.87 ± 0.13	0.06 ± 0.00	↓	< 0.001	1.06102
SM (d18:1/20:0)	17.6 ± 0.86	3.08 ± 0.31	↓	< 0.001	1.08689
SM (d18:1/19:0)	1.94 ± 0.20	0.21 ± 0.03	↓	< 0.001	1.07588
SM (d18:1/18:1)	39.0 ± 1.99	8.13 ± 0.58	↓	< 0.001	1.08637
SM (d18:1/18:0)	69.5 ± 2.72	9.07 ± 0.54	↓	< 0.001	1.08896
SM (d18:1/17:0)	14.1 ± 0.72	4.76 ± 0.39	↓	< 0.001	1.08307
SM (d18:1/16:0)	982 ± 38.5	629 ± 23.5	↓	< 0.001	1.06108
SM (d18:1/14:0)	27.3 ± 1.04	17.2 ± 0.65	↓	< 0.001	1.06732
SM (d18:0/24:0)	15.3 ± 0.78	0.11 ± 0.02	↓	< 0.001	1.08843
SM (d18:0/23:0)	2.45 ± 0.15	0.02 ± 0.00	↓	< 0.001	1.08694
SM (d18:0/22:0)	23.3 ± 1.05	0.23 ± 0.04	↓	< 0.001	1.08900
SM (d18:0/20:0)	4.59 ± 0.24	0.08 ± 0.01	↓	< 0.001	1.08808
SM (d18:0/19:0)	0.49 ± 0.07	0.01 ± 0.00	↓	< 0.001	1.05519
SM (d18:0/18:0)	17.0 ± 0.55	0.10 ± 0.03	↓	< 0.001	1.09013
SM (d18:0/17:0)	0.65 ± 0.07	0.06 ± 0.01	↓	< 0.001	1.07030
SM (d18:0/16:0)	545 ± 28.7	12.3 ± 0.94	↓	< 0.001	1.08809
SM (d18:0/15:0)	1.74 ± 0.16	0.10 ± 0.02	↓	< 0.001	1.08041
SM (d18:0/14:0)	5.83 ± 0.40	0.28 ± 0.03	↓	< 0.001	1.08565
Cer (d18:2/24:1)	1.01 ± 0.21	0.03 ± 0.01	↓	< 0.001	1.04397
Cer (d18:1/24:1)	46.1 ± 5.83	3.60 ± 0.44	↓	< 0.001	1.07110
Cer (d18:1/24:0)	42.0 ± 2.08	9.83 ± 0.41	↓	< 0.001	1.08653
Cer (d18:1/23:1)	1.37 ± 0.22	0.06 ± 0.01	↓	< 0.001	1.06057
Cer (d18:1/23:0)	2.54 ± 0.27	0.53 ± 0.09	↓	< 0.001	1.06941
Cer (d18:1/22:1)	1.20 ± 0.27	0.04 ± 0.01	↓	< 0.001	1.03542
Cer (d18:1/22:0)	14.4 ± 0.94	1.90 ± 0.39	↓	< 0.001	1.08443
Cer (d18:1/20:0)	1.69 ± 0.33	0.07 ± 0.02	↓	< 0.001	1.04721
Cer (d18:1/18:1)	20.1 ± 1.33	4.03 ± 0.49	↓	< 0.001	1.08187
Cer (d18:1/18:0)	8.03 ± 0.72	0.26 ± 0.04	↓	< 0.001	1.08142
Cer (d18:1/16:0)	52.0 ± 3.59	10.7 ± 0.98	↓	< 0.001	1.08243
Cer (d18:1/15:0)	3.14 ± 0.46	1.34 ± 0.30	↓	< 0.001	1.00100
Cer (d18:0/24:0)	1.44 ± 0.11	0.34 ± 0.04	↓	< 0.001	1.07587
Cer (d18:0/16:0)	3.46 ± 0.25	0.07 ± 0.01	↓	< 0.001	1.05883
HexCer (d18:1/26:0)	0.41 ± 0.10	0.04 ± 0.02	↓	< 0.001	1.00780
HexCer (d18:1/24:1)	9.25 ± 0.97	0.02 ± 0.00	↓	< 0.001	1.07959
HexCer (d18:1/16:0)	5.06 ± 0.89	21.6 ± 2.10	↑	< 0.001	1.07118
LacCer (d18:1/24:1)	0.22 ± 0.05	19.9 ± 2.17	↑	< 0.001	1.07014
LacCer (d18:1/24:0)	0.37 ± 0.03	56.4 ± 3.16	↑	< 0.001	1.07766
LacCer (d18:1/22:0)	0.06 ± 0.01	21.6 ± 2.85	↑	< 0.001	1.07258
LacCer (d18:1/16:0)	1.15 ± 0.55	115 ± 11.6	↑	< 0.001	1.08013
So (t17:1)	2.21 ± 0.17	0.62 ± 0.08	↓	< 0.001	1.07483