Table 4.
Effect of LYC on hepatic tissue antioxidant enzyme activities, lipid peroxidation level, caspase-3 immunoreactivity, and comet tail DNA % in BPA-intoxicated female Wistar rats.
| Parameter | Experimental groups | |||
|---|---|---|---|---|
| Control | LYC | BPA | BPA + LYC | |
| GPx (nmol/mg) | 99.06 ± 3.79b | 108.85 ± 2.95a | 61.14 ± 0.90d | 88.62 ± 1.71c |
| SOD (U/mg) | 7.60 ± 1.50a | 7.62 ± 0.01a | 5.74 ± 0.05c | 6.74 ± 0.04b |
| MDA (nmol/mg) | 0.54 ± 0.00c | 0.52 ± 0.01c | 0.93 ± 0.02a | 0.72 ± 0.02b |
| CYPR450 (ng/g) | 3.86 ± 0.04a | 3.98 ± 0.01a | 2.44 ± 0.04c | 3.44 ± 0.08b |
| Caspase-3 IRA (%) | 35.62 ± 4.82c | 42.74 ± 5.71c | 77.04 ± 2.97a | 61.86 ± 3.09b |
| Comet tail DNA (%) | 6.68 ± 1.04c | 6.94 ± 1.29 c | 25.05 ± 2.93a | 14.50 ± 2.61b |
Values are expressed as means ± SE (n = 7) in every group. BPA: bisphenol A; LYC: lycopene, GPx: glutathione peroxidase; SOD: superoxide dismutase, MDA: malondialdehyde, CYPR450: cytochrome P450 reductase; IRA: immunoreactive area. Within the same row, means with different superscript letters differ significantly at P ≤ 0.05.