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. 2018 Jul 25;2018:5906819. doi: 10.1155/2018/5906819

Figure 1.

Figure 1

Short term IFN-α stimulation is associated with altered expression of metabolic genes in human monocyte-derived macrophages (MDM) and mouse bone marrow-derived macrophages (BMM). (a) Workflow used to identify differentially expressed metabolic genes in IFN-α-stimulated mouse BMM (2.5 hours) and human MDM (4 hours). Metabolic genes were identified in MetScape using the Kyoto Encyclopedia of Genes and Genomes (KEGG) and the Edinburgh Human Metabolic Network (EHMN) databases. (b) Venn diagram showing the number of metabolic genes common to the BMM (yellow) and MDM (blue) datasets (FC > 1.2, p < 0.05, FDR < 0.10). (c) Principal component analysis (PCA) of metabolic gene sets from BMM (left) and MDM (right) following IFN-α stimulation (n = 517 and 354 metabolic genes in the BMM and MDM datasets, resp.).