Fig. 5.

Depletion of BAMs does not reduce infarct volume but attenuates the neurological deficit. a T2w MRI 24 h post-ischemia of representative rats per treatment group, i.e. clodronate (CL, n = 16) or vehicle (V, n = 17) liposomes. b Ischemia induced a similar drop of cortical perfusion (CBF) during MCAo, as assessed by laser Doppler, in both groups. The neurological score shows a small but significant improvement in the CL group. (Mann-Whitney test, * p = 0.046) There are no differences between groups in total infarct volume (b), as well as the volume of infarcted cortical and subcortical regions (not shown), as assessed by T2w MRI. Treatment, ischemia, neurological evaluation, MRI, and infarct volume measures were carried out in a blinded fashion