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. 2018 Aug 9;6:76. doi: 10.1186/s40478-018-0581-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Effects of BAM depletion on leukocyte infiltration after brain ischemia. Rats received clodronate (CL) or vehicle (V) liposomes in the left ventricle 4 days before occlusion of the right middle cerebral artery and the brain was analyzed 1 day after ischemia. a) mRNA was extracted from the contralateral (control) and ipsilateral (ischemic) brain hemispheres of rats treated with V (n = 7) or CL (n = 6) for qRT-PCR analysis. Values are expressed as fold versus the mean value in the control V group. CL does not reduce leukocyte chemoattractants that were upregulated by ischemia in CD163⁺ macrophages (see Fig. 3), such as Spp1, C1qbp, Il6, and Ccl17. b) Flow cytometry analysis of the brain hemisphere of control rats (n = 11 vehicle, V; n = 9 CL) and ischemic rats (n = 12 V; n = 11 CL) illustrates leukocyte infiltration in the ischemic group. c) Depletion of CD163⁺ macrophages (CL group) reduces the percentage of REA535⁺ granulocytes in the infiltrating myeloid cell population (CD45^hiCD11b⁺) (*p = 0.039)