Table 3.
Genetic models | OR (95% CI) | p value | Heterogeneity | Effects model | |
---|---|---|---|---|---|
I 2 (%) | p value | ||||
Allele model (A versus G) | |||||
Overall | 1.20 (0.97, 1.47) | 0.09 | 83 | 0.00001 | R |
Race | |||||
Chinese Han | 1.46 (0.86, 2.48) | 0.16 | 91 | <0.0001 | R |
Caucasian | 1.11 (1.01, 1.22) | 0.03 | 0 | 0.62 | R |
| |||||
Dominant model (AA + GA versus GG) | |||||
Overall | 1.30 (0.97, 1.74) | 0.08 | 73 | 0.001 | R |
Race | |||||
Chinese Han | 1.54 (0.91, 2.61) | 0.11 | 83 | 0.0006 | R |
Caucasian | 1.17 (0.91, 1.49) | 0.22 | 17 | 0.30 | R |
| |||||
Recessive model (AA versus GA + GG) | |||||
Overall | 1.23 (0.81, 1.86) | 0.34 | 77 | 0.0002 | R |
Race | |||||
Chinese Han | 1.35 (0.54, 3.39) | 0.52 | 87 | <0.0001 | R |
Caucasian | 1.20 (0.94, 1.51) | 0.14 | 0 | 0.39 | R |
| |||||
Heterozygous genetic model (GA versus GG) | |||||
Overall | 1.24 (0.96, 1.59) | 0.10 | 58 | 0.03 | R |
Race | |||||
Chinese Han | 1.42 (0.94, 2.15) | 0.09 | 67 | 0.03 | R |
Caucasian | 1.09 (0.81, 1.49) | 0.56 | 38 | 0.20 | R |
| |||||
Homozygous genetic model (AA versus GG) | |||||
Overall | 1.34 (0.83, 2.15) | 0.23 | 78 | 0.0001 | R |
Race | |||||
Chinese Han | 1.53 (0.57, 4.15) | 0.40 | 88 | <0.0001 | R |
Caucasian | 1.30 (0.98, 1.73) | 0.07 | 0 | 0.42 | R |
F: fixed-effect model; R: random-effect model; OR: odds ratio; 95% CI: 95% confidence interval.