Table 2.
| Category | CYP2A6 | P value | CYP2C8 | P value | ||
|---|---|---|---|---|---|---|
| High | Low | High | Low | |||
| GSE14520 | ||||||
| HBV viral status (AVR-CC/CC/NA) | 25/81/4 | 31/74/5 | 0.635 | 28/78/4 | 28/77/5 | 0.943 |
| Alanine aminotransferase (>50/<50, U/L) | 38/72 | 51/59 | 0.099 | 42/68 | 47/63 | 0.583 |
| Main tumor size (>5/<5/NA, cm) | 34/76/0 | 44/65/1 | 0.16 | 33/77/0 | 45/64/1 | 0.091 |
| Multinodular (yes/no) | 18/92 | 27/83 | 0.181 | 21/89 | 24/86 | 0.738 |
| Cirrhosis (yes/no) | 101/9 | 101/9 | 1.0 | 101/9 | 101/9 | 1.0 |
| TNM staging (I/II/III/NA) | 57/37/15/1 | 36/40/33/1 | 0.005 | 56/33/21/0 | 37/44/27/2 | 0.032 |
| BCLC staging (0-A/B/C/NA) | 83/9/7/1 | 75/13/21/1 | 0.039 | 79/8/13/0 | 79/14/15/2 | 0.357 |
|
| ||||||
| GSE36376 | ||||||
| Edmondson grade (I/II/III) | 16/100/4 | 8/97/15 | 0.01 | 19/96/5 | 5/101/14 | 0.002 |
| Tumor size (median), mm | 34 (31) | 40 (45) | 0.203 | 34 (30) | 42 (45) | 0.081 |
| Vascular invasion (yes/no) | 51/69 | 84/36 | <0.001 | 51/69 | 84/36 | <0.001 |
| Major portal vein invasion (yes/no) | 1/119 | 8/112 | 0.036 | 1/119 | 8/112 | 0.036 |
| Intrahepatic metastasis (yes/no) | 17/103 | 38/82 | 0.002 | 18/102 | 37/83 | 0.005 |
| Multicentric occurrence (yes/no) | 8/112 | 5/115 | 0.57 | 7/113 | 6/114 | 1.0 |
| Direct invasion of adjacent organ (yes/no) | 3/117 | 2/118 | 1.0 | 3/117 | 2/118 | 1.0 |
| AJCC staging (1/2/3/4) | 66/43/8/3 | 36/57/25/2 | <0.001 | 67/42/8/3 | 35/58/25/2 | <0.001 |
| BCLC staging (A/B/C) | 75/43/2 | 64/48/8 | 0.092 | 80/38/2 | 59/53/8 | 0.009 |
| Alpha fetoprotein [Median (IQR), ng/ml] | 9.65 (82.2) | 256.6 (4136.8) | <0.001 | 9.1 (61.6) | 303.8 (9534.45) | <0.001 |
NA: not available; AVR-CC: active viral replication chronic carrier; CC: chronic carrier; IQR: interquartile range;