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. 2018 Aug 2;9:332. doi: 10.3389/fpsyt.2018.00332

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Copyright © 2018 Shen, Song, Guo, Xu, Li, Zhang, Ma, Zhang, Lin, Li and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Repeated sevoflurane exposure abolished LTP in the hippocampus. (A) Schematic representation of bipolar stimulating and recording electrode placement. (B) Tetanic stimulation (one bout of stimulation at 100 Hz) induced LTP in the Schaffer collateral-CA1 pathway of rat hippocampal slices. (C) Representative traces of the fEPSP waves were recorded at baseline (the black line) and after repeated sevoflurane exposure (the gray line); early-life sevoflurane exposure impaired LTP in the rat hippocampus. N = 9 slices, 4 rats for the control group; n = 8 slices, 4 rats for the sevo group.