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. 2018 Aug 8;19:295. doi: 10.1186/s12859-018-2289-9

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Allele matching for polygenic risk scores (PRS) between discovery and target data. The effect alleles and their reverse complements are indicated in red. Matching the effect alleles from the discovery data with the reported alleles in the target data is straightforward when SNPs are not strand-ambiguous (top and middle panel). The allele in the target data can be misassigned for strand-ambiguous SNPs (bottom)