Fig. 4.

Curcumin binding in non-AD pathologies. Curcumin staining of PART, FTLD-tau, FTLD-TDP-43, and PD cases (a-e). Fluorescent co-stainings for comparison of curcumin and tau (FTLD-tau), TDP-43 (FTD-TDP-43), and α-synuclein (PD) (f-j). Immunohistochemical DAB stainings for tau (AT8), TDP-43 (pTDP-43) and α-synuclein (LB-509) are shown for reference (k-o). Scale bars a-j 50 μm. Scale bars k-o 100 μm. Abbreviations: DAPI = 4′,6-diamidino-2-fenylindole, FTLD-tau = frontotemporal lobe degeneration with tau pathology, FTLD-TDP-43 = frontotemporal lobe degeneration with TDP-43 pathology, PART = primary age related tauopathy