Table 4.

Overview of binding of different curcumin forms to different pathological deposits

Staining of different pathological deposits by different curcumin forms was qualitatively compared for different plaque types, cerebral amyloid angiopathy (CAA) and neurofibrillary tangles (NFTs). Immuno-histochemical (IHC) stainings for amyloid-beta (4G8, plaques and CAA) and phosphorylated tau (AT-8, NFT’s) are shown for reference. Scalebar 50 μm

++: clearly visible, +: visible, +/−: visible with appreciation of morphology. *The staining of the core of cored plaques rather than the corona was assessed here

Abbreviations: BDMC bis-demethoxycurcumin, DMC demethoxycurcumin