Table 3.
Effect of C. chayamansa extract on the biochemical parameters of Balb/C mice with hepatotoxicity induced by antiTB drugs.
| Parameters | Treatments | |||
| AntiTB | AntiTB + Silymarin | AntiTB + CnCM | ||
|
| ||||
| 2.5 mg/kg | 200 mg/kg | 400 mg/kg | ||
|
| ||||
| Creatinine (mg/dL) |
2.88±0.79 | 2.88±0.21 | 0.60±0.25ab | 0.07±0.07ab |
| Urea (mg/dL) |
51.07±5.63 | 68.45±5.00 | 50.63±8.43b | 40.55±1.93ab |
| AST (IU/L) |
198.00±17.45 | 256.33±25.32a | 268.00±13.46a | 317.00±8.62abc |
| ALT (IU/L) |
175.00±32.25 | 228.33±31.09a | 393.00±76.08ab | 452.50±59.29ab |
| ALP (IU/L) |
184.00±28.65 | 286.00±11.93a | 252.67±38.27a | 397.00±7.09abc |
| Cholesterol (mmol/L) |
4.30±0.25 | 4.50±0.24 | 4.23±0.30 | 4.10±0.05 |
| Triacyl-glyceride (mmol/L) |
0.99±0.20 | 1.36±0.31 | 0.66±0.10 | 0.70±0.03 |
| HDL (mmol/L) |
1.30±0.06 | 1.05±0.07a | 0.92±0.01ab | 0.92±0.01ab |
Data presented as mean (±) standard error of the mean (SEM). Statistical analysis one-way ANOVA, post hoc Student-Newman-Keuls (SNK) test (p<0.05); avs AntiTB; bvs AntiTB + Silymarin 2.5 mg/kg; cvs AntiTB + CnCM 200 mg/kg; dvs AntiTB + CnCM 400 mg/kg; AntiTB: RIF/INH/PZA mixture; AST: aspartate aminotransferase; ALT: alanine aminotransferase; ALP: alkaline phosphatase; HDL: high density lipoprotein; n=7.