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Antagonistic activity of synthesized compounds against CXCR2.
 | ||||||
|---|---|---|---|---|---|---|
| no. | R1 | R2 | R3 | CXCR2 IC50 (μM) | s.e.m. | fit value |
| 1a | –CON(CH3)2 | H | –C6H5 | 76 | 5.6 | 5.95807 |
| 2 | — | — | — | >100 | — | 2.78005 |
| 3 | — | — | — | >100 | — | — |
| 1b | H | CN | –C6H5 | 18.5 | 3.7 | 4.69647 |
| 1c | H | CN | 2-Br-C6H4 | 25.4 | 8.6 | 4.81771 |
| 1d | H | CN | 4-CF3-C6H4 | >100 | — | 4.87115 |
| 1e |  |
Cl | –C6H5 | 14.8 | 9.6 | 5.98048 |
| MK7123 | — | — | — | 0.008 | 0.003 | 6.99950 |
