Fig. 5. Chlorambucil, chlordinaline and tacedinaline induce DNA damage in A375 cells. A375 cells were treated with chlordinaline, chlorambucil and tacedinaline at 8 μM or 16 μM for 48 hours. Data were expressed as the percent of the control (no drug treatment), as mean ± SD (n = 3). P-Values were determined using a t-test (* indicates p < 0.05, ** indicates P < 0.01, *** indicates P < 0.001).