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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: J Allergy Clin Immunol. 2018 Jul;142(1):1–8. doi: 10.1016/j.jaci.2018.05.001

Figure 1. Food and Aeroallergen Antigens in EoE.

Figure 1

Ingested and inhaled antigens, in conjunction with acid and proteases, activate the epithelium to produce chemotactic and activating factors for innate (mast cells, basophils, iNKT, innate lymphoid cells) and adaptive (T cells) immune cells. Infiltrating cells can produce Th2 cytokines such as IL-13 and IL-4 as well as pro-fibrotic factors. Chronic inflammation initiates tissue remodeling with resultant dysphagia, food impactions, and strictures.