Table 3.
Incidence Rates of Serious Infection Subtypes: THIN Cohort
| Serious Infection Type | No Psoriasis N=954,315 |
All Psoriasis N=199,700 |
Mild Psoriasis N=187,258 |
Moderate-to-Severe Psoriasis N=12,442 |
||||
|---|---|---|---|---|---|---|---|---|
| N (%) | Ratea (95% CI) | N (%) | Ratea (95% CI) | N (%) | Ratea (95% CI) | N (%) | Ratea (95% CI) | |
| Lower respiratory tract | 16,156 (1.7) | 26.1 (25.7, 26.5) | 3,571 (1.8) | 29.0 (28.1, 30.0) | 3,244 (1.7) | 27.8 (26.9, 28.8) | 327 (2.6) | 49.8 (44.7, 55.5) |
| Skin and soft tissue | 7,426 (0.78) | 11.9 (11.7, 12.2) | 2,022 (1.0) | 16.4 (15.7, 17.1) | 1,817 (0.97) | 15.5 (14.9, 16.3) | 205 (1.6) | 31.1 (27.1, 35.6) |
| Upper respiratory tract | 8,631 (0.90) | 13.9 (13.6, 14.2) | 2,006 (1.0) | 16.3 (15.6, 17.0) | 1,817 (0.97) | 15.6 (14.9, 16.3) | 189 (1.5) | 28.7 (24.9, 33.1) |
| Urinary tract | 7,956 (0.83) | 12.8 (12.5, 13.1) | 1,581 (0.79) | 12.8 (12.2, 13.4) | 1,447 (0.77) | 12.4 (11.7, 13.0) | 134 (1.1) | 20.2 (17.1, 24.0) |
| Conjunctivitis | 1,491 (0.16) | 2.4 (2.3, 2.5) | 348 (0.17) | 2.8 (2.5, 3.1) | 325 (0.17) | 2.8 (2.5, 3.1) | 23 (0.18) | 3.5 (2.3, 5.2) |
| Gastrointestinal | 1,334 (0.14) | 2.1 (2.0, 2.3) | 312 (0.16) | 2.5 (2.3, 2.8) | 279 (0.15) | 2.4 (2.1, 2.7) | 33 (0.27) | 5.0 (3.5, 7.0) |
| Sepsis | 1,257 (0.13) | 2.0 (1.9, 2.1) | 305 (0.15) | 2.5 (2.2, 2.8) | 269 (0.14) | 2.3 (2.0, 2.6) | 36 (0.29) | 5.4 (3.9, 7.5) |
| Cholecystitis/cholangitis | 1,271 (0.13) | 2.0 (1.9, 2.2) | 253 (0.13) | 2.0 (1.8, 2.3) | 234 (0.12) | 2.0 (1.8, 2.3) | 19 (0.15) | 2.9 (1.8, 4.5) |
| Abdominal abscess | 177 (0.019) | 0.28 (0.25, 0.33) | 43 (0.022) | 0.35 (0.26, 0.47) | 42 (0.022) | 0.36 (0.26, 0.48) | 1 (0.008) | 0.15 (0.02, 1.1) |
| Septic arthritis | 128 (0.013) | 0.20 (0.17, 0.24) | 39 (0.020) | 0.31 (0.23, 0.43) | 31 (0.017) | 0.26 (0.19, 0.38) | 8 (0.064) | 1.2 (0.60, 2.4) |
| Osteomyelitis | 127 (0.013) | 0.20 (0.17, 0.24) | 35 (0.018) | 0.28 (0.20, 0.39) | 32 (0.017) | 0.27 (0.19, 0.39) | 3 (0.024) | 0.45 (0.15, 1.4) |
| Breast abscess | 108 (0.011) | 0.17 (0.14, 0.21) | 34 (0.017) | 0.27 (0.20, 0.38) | 31 (0.017) | 0.26 (0.19, 0.38) | 3 (0.024) | 0.45 (0.15, 1.4) |
| Endocarditis | 58 (0.006) | 0.093 (0.072, 0.12) | 12 (0.006) | 0.097 (0.055, 0.17) | 11 (0.006) | 0.094 (0.052, 0.17) | 1 (0.008) | 0.15 (0.02, 1.07) |
| Prostate | 38 (0.004) | 0.061 (0.044, 0.084) | 8 (0.004) | 0.064 (0.032, 0.13) | 7 (0.004) | 0.060 (0.028, 0.13) | 1 (0.008) | 0.15 (0.021, 1.1) |
| Central nervous system | 37 (0.004) | 0.059 (0.043, 0.082) | 8 (0.004) | 0.064 (0.032, 0.13) | 8 (0.004) | 0.068 (0.034, 0.14) | 0 | 0 |
| Device-associated | 6 (0.0006) | 0.0096 (0.004, 0.021) | 3 (0.0015) | 0.024 (0.008, 0.075) | 3 (0.0016) | 0.026 (0.008, 0.079) | 0 | 0 |
| Central nervous system abscess | 6 (0.0006) | 0.0096 (0.004, 0.021) | 2 (0.001) | 0.016 (0.004, 0.064) | 2 (0.001) | 0.017 (0.004, 0.068) | 0 | 0 |
CI, confidence interval
a
Per 10,000 person-years