Fig. 2. Modelled overlay of diphosphates derived from nucleosides 9a, 17a, 23a and ADP in the co-crystal structure of the viral RNA-dependent RNA polymerase HCV NS5B genotype 2A in complex with RNA template, primer, Mn2+, and ADP (PDB code ; 4WTJ, 2.2 Å resolution). a) Detail of the tricyclic base overlayed with ADP; b) detail of ribose binding site, hydrogen bonds of 2′-OH showed as dashed lines and given in Å. Color code: Cenzyme grey, CADP magenta, C9a-DP salmon, C17a-DP yellow, C23a-DP cyan, CRNA green, O red, N blue, F pale cyan.
