Table 1. Synthesis of 2′-deoxy-2′-fluoroarabinonucleosides 8 and 9.
Entry | R | Conditions | Protected nucleoside | Yield [%] | Final nucleoside | Yield [%] |
1 | NH2 | b | — | — | 9a | 78 |
2 | OMe | c | — | — | 9b | 22 |
3 | SMe | d | — | — | 9c | 32 |
4 | Me | e | 8d | 46 | 9d | 78 |
5 | 2-Furyl | g | 8e | 79 | 9e | 69 |
6 | 3-Furyl | f | 8f | 77 | 9f | 33 |
7 | 2-Thienyl | g | 8g | 51 | 9g | 78 |
8 | 3-Thienyl | f | 8h | 53 | 9h | 65 |
9 | Phenyl | f | 8i | 55 | 9i | 65 |