Table 4. Anti-HCV and anti-dengue activities of nucleosides.
| Compd | HCV (1B) |
HCV (2A) |
Dengue type 2 |
||||||
| EC50 (μm) | CC50 (μm) | SI | EC50 (μm) | CC50 (μm) | SI | EC50 (μm) | CC50 (μm) | SI | |
| 9a | 6.7 | >44.4 | >6.6 | >44.4 | 33.1 | 0.75 | 10.8 | 12.7 | 1.2 |
| 9b | 3.1 | >44.4 | >14.3 | 10.8 | >44.4 | >4.1 | >50 | >50 | — |
| 9c | 1.6 | 22.9 | 14.3 | 6.9 | 20.2 | 2.9 | >50 | >50 | — |
| 9d | 6.3 | >44.4 | >7.0 | 23.2 | >44.4 | >1.9 | >50 | >50 | — |
| 9e | 4.6 | >44.4 | >9.7 | 14.7 | 34.6 | 2.4 | 10.5 | 39.0 | 3.7 |
| 9f | 23.0 | >44.4 | >1.9 | >44.4 | >44.4 | — | >50 | >50 | — |
| 9g | 2.5 | >44.4 | >17.8 | 13.9 | 34.3 | 2.5 | 27.9 | 39.1 | 1.4 |
| 9h | 4.1 | 26.5 | 6.5 | 16.2 | 30.3 | 1.9 | 33.3 | >50 | 1.5 |
| 9i | 5.2 | >44.4 | >8.5 | 15.7 | 34.4 | 2.2 | >50 | >50 | — |
| 16 | 13.7 | 32.5 | 2.4 | 17.4 | 21.4 | 1.2 | 17.4 | 40.9 | 2.4 |
| 17a | 22.3 | >44.4 | >2.0 | >44.4 | >44.4 | — | >50 | >50 | — |
| 17c | 17.4 | >44.4 | >2.6 | 38.5 | >44.4 | >1.2 | >50 | >50 | — |
| 17d | 18.5 | 40.2 | 2.2 | >44.4 | >44.4 | — | >50 | >50 | — |
| 17e | 3.0 | >44.4 | >14.8 | 24.0 | >44.4 | >1.9 | >50 | >50 | — |
| 22 | 4.7 | 9.1 | 1.9 | 9.5 | 10.3 | 1.1 | >50 | >50 | — |
| 23a | 4.7 | >44.4 | >9.4 | >44.4 | >44.4 | — | >50 | >50 | — |
| 23b | 8.7 | >44.4 | >5.1 | >44.4 | >44.4 | — | >50 | >50 | — |
| 23c | 6.6 | 29.0 | 4.5 | 17.0 | >44.4 | >2.6 | >50 | >50 | — |
| 23d | 5.2 | >44.4 | >8.5 | 16.1 | >44.4 | >2.8 | >50 | >50 | — |
| 23e | 2.3 | >44.4 | >19.3 | 15.7 | >44.4 | >2.8 | >50 | >50 | — |
| 23f | 5.2 | >44.4 | >8.5 | 21.8 | >44.4 | >2.0 | >50 | >50 | — |
| 23g | 18.4 | >44.4 | >2.4 | 19.7 | >44.4 | >2.3 | >50 | >50 | — |
| 23h | 25.1 | >44.4 | >1.8 | >44.4 | >44.4 | — | >50 | >50 | — |
| 23i | 8.2 | >44.4 | >5.4 | 20.3 | >44.4 | >2.2 | >50 | >50 | — |
| Mericitabine | 1.2 | >44.4 | >37 | 0.99 | >44.4 | >44 | nt | nt | — |