Figure 2.

Histopathological study of H&E-stained liver sections of different groups of mice infected with Schistosoma mansoni.

Notes: Infected untreated group showing: (A) multiple granulomas of variable sizes and shapes with preserved hepatic architecture (×100); (B) cellular granuloma composed of lymphocytes, histiocytes, epithelioid cells, and eosinophil cells, surrounding the bilharzial egg (×400); (C) Kupffer cell hyperplasia and bilharzial pigment (×400); (D) fatty changes in hepatocytes (×400); (E) hepatic sinusoids with lymphocytic infiltration (×400); and (F) infected PZQ suspension-treated mice (×100); (G) infected PZQ–LNC-25-treated mice (×100), and (H) infected PZQ–OA–MFS–LNC-25-treated mice (×100) showing small cellular granulomas with mild amelioration of liver pathology.

Abbreviations: LNC, lipid nanocapsules; MFS, miltefosine; OA, oleic acid; PZQ, praziquantel.