Fig. 6. Docking poses on EGFR. A) 2D structure of a chalcone-linked pyrazolo[1,5-a]pyrimidine with observed interactions with EGFR; B) binding pose of 6j (yellow color, EGFR is shown in green and hydrogen bonds are shown by the red dotted lines); C) superimposed pose of 6j and erlotinib; D) superimposed pose of 6j and 7a showing the difference in hydrogen bonding between the carbonyl carbons and Cys773.