Table 2. The cytotoxic activity (IC₅₀) ^a of the podophyllotoxin 4β-amido [(4-substituted)-1,2,3-triazol-1-yl] podophyllotoxin derivatives (9a–l).

Compound	MCF-7 b	B16 c	HT29 d	HeLa e
9a	8.1	21.5	20.1	19.6
9b	17.1	23.5	22.5	16.8
9c	11.3	10.6	18.6	0.9
9d	15.8	22.4	13.9	17.9
9e	22.4	10.8	10.6	2.3
9f	21.9	22.5	15.6	25.4
9g	38.2	23.6	17.5	28.4
9h	14.5	19.5	18.4	23.6
9i	8.9	18.2	19.5	6.5
9j	0.9	10.1	0.1	0.07
9k	7.2	14.7	18.5	2.6
9l	6.9	14.3	13.6	15.4
Podophyllotoxin	3.75	2.12	1.26	2.36
Etoposide	1.36	1.85	1.98	2.24

^a50% Inhibitory concentration after 48 h of drug treatment.

^bHuman breast cancer.

^cMacrophage cancer.

^dHuman colon cancer.

^eHuman cervical cancer.