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. 2018 Aug;76:295–307. doi: 10.1016/j.actbio.2018.05.053

Fig. 3.

Fig. 3

Tissue and fibrillar level mechanics: (A–D) Tissue level stress plotted as a function of fibril strain for femoral cortical bone from Crh−120/+ and Crh+/+ mice aged (A) 8 weeks, (B) 12 weeks, (C) 24 weeks and (D) 36 weeks. Straight lines are linear regressions (solid black: Crh+/+; dashed gray: Crh−120/+) (E) Tissue level modulus (GPa) plotted as a function of genotype and developmental age. (F) Effective fibril modulus (GPa) plotted as a function of genotype and developmental age. (G) Maximum stress (MPa) plotted as a function of genotype and developmental age. (H) Maximum fibril strain (%) plotted as a function of genotype and developmental age. Error bars shown are standard deviations. Student’s t-tests were performed to determine if there are statistical significance in the differences between effective fibril modulus, maximum fibril strain, tissue modulus, and maximum stress between Crh+/+ and Crh−120/+ mice at four developmental ages. Statistical significance is denoted (*p < 0.05, **p < 0.01, ***p < 0.001, ns: not significant).