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. 2017 Apr 18;114(7):1495–1510. doi: 10.1002/bit.26280

Figure 1.

Figure 1

Transient transfection of miRNA mimics in seven different recombinant CHO production cell lines. Cells were transfected either with hsa‐miR‐557 mimics or non‐target siRNAs (NT‐siRNA) and cultured for 96 h in agitated 96‐well format. Product quantification was performed using Protein A coupled biosensors on an Octet® QK384. mAb productivity of miR‐557 transfected cells was normalized to NT‐siRNA transfected control cells. Data are presented as mean value and error bars represent the standard deviation (SD) of three independent transfections. Testing of statistical significance between control and miRNA transfected CHO production cell lines was performed by applying an unpaired two‐tailed t‐test (**P < 0.01; ***P < 0.001).